A study from Finland following 332,202 women who stopped taking HRT between 1994 and 2009, reported an increase in mortality rate from cardiac death or stroke compared both to the baseline population and to women who continued taking HRT.
There did appear to be an age effect with an increase in mortality shown if HRT stopped under age 60, but no increase if HRT stopped after age 60.
This study adds to the increasing evidence that use of HRT up to the age of 60 provides many benefits and may be harmful to stop too early.
Ref Mikkola TS, Tuomikoski P, Lyytinen H, et al. Increased cardiovascular mortality risk in women discontinuing postmenopausal hormone therapy. J Clin Endocrinol Metab 2015;100:4588-94